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ISAVRAD Research Projects

Learn more about each Research Projects that makes ISAVRAD run smoothly.

Project 1: Longitudinal Epidemiology

Describes the longitudinal course, epidemiological risk/resiliency factors, and environmental interactions predictive of cognitive decline and progress to ADRD following SARS-CoV-2 infection in adults over 60 years of age from ancestral and admixed populations.

Project 2: Gene x Environment Interactions

Assesses the genetic basis of ADRD-relevant endophenotypic response to SARS-CoV-2 infection in a set of older (>60 years of age) adults from diverse populations (Amerindians from Argentina [ n=3000], US Native Americans [n=250], Mexican Americans [n=500], Puerto Ricans [n=125], African Americans [n=125], and Africans [n=300]) using whole genome sequence (WGS) data in a case/control design (75% post-infection cases, 25% never infected controls).

Project 3: Neuroimaging

Discover neural signatures of COVID-19-associated cognitive impairment at the group-contrast level using volumetric, surface-based, and tract-based metrics.

Project 4: Biomarkers

Link well-validated BBB to history of infection as well as measures of brain structure and function.

The ISAVRAD Consortium explores how COVID-19 and genetics affect brain health, focusing on diverse communities worldwide.

RESEARCH

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